Characteristics of systemic growth activation by 9,10-ketol-12(),15()-octadecadienoic acid (KODA) in cultured in vitro.

α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action different from jasmonic acid, such as promotion of flower formation, activation of rooting, increase of shoot germinating in spring, and breaking endodormancy. We report here that KODA promotes the systemic growth in juvenile cultured in vitro probably through the activation of immature tissue.

Endoscopic ultrasonography-guided removal of a stent that had migrated into the pancreas post-pancreaticojejunostomy: A case report.

A 64-year-old woman had undergone subtotal stomach-preserving pancreaticoduodenectomy for locally advanced pancreatic head cancer. She had an uneventful postoperative course with no recurrence. However, approximately 18 months after surgery, she presented with recurrent abdominal pain.

The Association Between the Dietary Fatty Acid Fraction and Healthy Life Expectancy: Global Spatiotemporal Epidemiology from 2010 to 2019.

Background: As the global population ages, extending not only the life expectancy (LE) but also the healthy life expectancy (HALE) has become a critical public health objective. Dietary choices, especially the intake of various fatty acids, may play a role in achieving good health.

Objective: The aim of this study was to describe the intake of fatty acid (FA) fractions across different countries and explore its associations with HALE and LE from 2010 to 2019 according to publicly available international data.

Microsatellite-high intrahepatic cholangiocarcinoma with favorable treatment outcome using pembrolizumab.

Intrahepatic cholangiocarcinoma has a poor prognosis. In unresectable cases, the survival period is short despite combination therapy with cytotoxic anticancer agents and immune checkpoint inhibitors. The usefulness of immune checkpoint inhibitors against malignant tumors with microsatellite instability-high (MSI-H) mutations was shown in the KEYNOTE158 study; however, data for intrahepatic cholangiocarcinoma are insufficient.

Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report.

Background: Heterozygous familial hypobetalipoproteinemia (FHBL) is a semi-autosomal disorder that is caused mainly by an variant. It is usually asymptomatic and rarely leads to non-alcoholic steatohepatitis (NASH).

Case Summary: A 12-year-old boy was referred to our hospital after prolonged elevation of liver enzymes was observed during health checkups in Kagawa Prefecture.