Publications by authors named "K Middelkoop"
Article Synopsis
- The study aimed to evaluate if vitamin D supplementation affects grip strength, leg power, cardiorespiratory fitness, and exercise-induced bronchoconstriction (EIB) in South African schoolchildren aged 8-11.
- Conducted in Cape Town, the study involved 450 children who received either 10,000 IU of vitamin D or a placebo weekly for three years, with various fitness measures assessed at the end of the study.
- While vitamin D supplementation significantly increased serum 25(OH)D levels, it did not lead to improvements in grip strength, explosive leg power, overall fitness, or reduce the risk of EIB in the participants.
Article Synopsis
- The study focuses on childhood TB infection prevalence, incidence, and risk factors in Cape Town, South Africa, highlighting the importance of understanding TB transmission.
- Using a large sample of primary school children from high TB burden areas, researchers measured TB infection at baseline and tracked changes over three years through the QFT-Plus test.
- Findings indicate a high prevalence of TB infection (22.6%) associated with factors like age and household exposure to TB, emphasizing the need for effective contact tracing and early treatment to reduce transmission in the community.
Introduction: HPTN 083 demonstrated the superiority of long-acting cabotegravir (CAB-LA) versus daily oral emtricitabine/tenofovir disoproxil fumarate (TDF/FTC) as pre-exposure prophylaxis (PrEP) among cisgender men and transgender women who have sex with men (MSM/TGW). HPTN 083 provided the first opportunity to understand experiences with injectable PrEP in a clinical trial.
Methods: Participants from two US sites (Chicago, IL and Atlanta, GA) and one international site (Rio de Janeiro, Brazil) were purposively sampled for individual qualitative interviews (N = 40), between November 2019 and March 2020, to explore trial experiences, barriers to adherence and other factors that may have impacted study implementation or outcomes.
Article Synopsis
- - The study aimed to see if weekly vitamin D supplementation affects growth, body composition, pubertal development, or lung function in South African schoolchildren aged 6-11 years, through a rigorous 3-year double-blind trial.
- - 1682 children participated, with one group receiving 10,000 IU of vitamin D weekly and a control group receiving a placebo, while growth and health measures were closely monitored.
- - Results showed that while vitamin D levels increased significantly in the supplemented group, there were no meaningful changes in growth, body composition, or lung function compared to the placebo group.
Article Synopsis
- There is a lack of randomized controlled trials (RCTs) investigating the impact of vitamin D on bone mineral content (BMC) and fracture risk in Black African children, leading to this sub-study among 450 Cape Town schoolchildren aged 6-11.
- The study found that after a 3-year vitamin D supplementation of 10,000 IU weekly, participants had higher serum vitamin D levels and lower parathyroid hormone (PTH) levels, but no significant differences in BMC or bone turnover markers between the vitamin D and placebo groups.
- Fractures were infrequent in both the vitamin D and placebo groups, suggesting that while vitamin D supplementation improved some biochemical markers, it did not significantly affect bone density or