Publications by authors named "K Michie"
Article Synopsis
- Sexual reproduction in malaria parasites is crucial for their transmission to mosquitoes and helps researchers explore the evolution of sexual reproduction across different eukaryotes.
- A genetic study of Plasmodium berghei has identified 348 genes involved in sex and transmission, revealing new targets for potential interventions to block transmission.
- The study highlights the importance of two proteins, SUN1 and ALLC1, in male fertility by connecting cellular structures necessary for sperm development, suggesting a long-standing role for these proteins across species, including in mouse testes.
Article Synopsis
- Hypomethylating agents (HMAs) are key treatments for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML), but patients often develop resistance and experience treatment failure.
- Researchers conducted a genome-wide CRISPR-Cas9 screen in MDS-derived cells, discovering that targeting the gene TOPORS enhances the effectiveness of HMAs by making cancer cells more vulnerable to DNA damage.
- The study suggests that combining HMAs with strategies to inhibit SUMOylation or TOPORS could be an effective treatment approach for patients with high-risk MDS or AML, without harming normal blood cell production.
Background: The unfolded protein response (UPR) is a proteostatic process that is activated in response to endoplasmic reticulum stress. It is currently unclear how aging influences the chronic and adaptive UPR in human skeletal muscle. Here we determined the effect of aging on UPR activation at rest, in response to exercise, and the associations with muscle function.
View Article and Find Full Text PDFInfections caused by methicillin-resistant Staphylococcus aureus (MRSA) are alarmingly common, and treatment is confined to last-line antibiotics. Vancomycin is the treatment of choice for MRSA bacteremia, and treatment failure is often associated with vancomycin-intermediate S. aureus isolates.
View Article and Find Full Text PDFCryptophyte algae have a unique phycobiliprotein light-harvesting antenna that fills a spectral gap in chlorophyll absorption from photosystems. However, it is unclear how the antenna transfers energy efficiently to these photosystems. We show that the cryptophyte Hemiselmis andersenii expresses an energetically complex antenna comprising three distinct spectrotypes of phycobiliprotein, each composed of two αβ protomers but with different quaternary structures arising from a diverse α subunit family.
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