Tezepelumab inhibits highly functional truncated thymic stromal lymphopoietin in chronic rhinosinusitis.

Background: Thymic stromal lymphopoietin (TSLP) and its functional cleavage products are elevated in nasal polyps (NPs) and play important roles in type 2 (T2) inflammation in chronic rhinosinusitis (CRS) with NPs (CRSwNP) by activating myeloid dendritic cells (mDCs) and group 2 innate lymphoid cells (ILC2s). However, whether tezepelumab, a human monoclonal antibody against TSLP, inhibits functional cleaved TSLP and the role of TSLP in CRS without NPs (CRSsNP) have not been studied.

Objective: To investigate the effects of tezepelumab on cleaved TSLP in CRS.

Perioperative glucagon-like peptide-1 receptor agonist use and retained gastric contents: A retrospective analysis of patients undergoing elective upper endoscopy.

Introduction: Glucagon-like peptide-1 receptor (GLP-1R) agonists have been increasingly prescribed for weight loss and glycemic control. The potential side effect of slowed gastric emptying may increase risk of regurgitation and aspiration. Our primary aim was to investigate the incidence of retained gastric contents (RGCs) among appropriately fasted patients taking a GLP-1R agonist compared to those not taking a GLP-1R agonist presenting for upper gastrointestinal endoscopy (UE).

DNA data (genome skims and metabarcodes) paired with chemical data demonstrate utility for retrospective analysis of forage linked to fatal poisoning of cattle.

Prepared and stored feeds, fodder, silage, and hay may be contaminated by toxic plants resulting in the loss of livestock. Several poisonous plants have played significant roles in livestock deaths from forage consumption in recent years in the Western United States including Salvia reflexa. Metagenomic data, genome skims and metabarcodes, have been used for identification and characterization of plants in complex botanical matrices including diet composition of animals, mixed forages, and herbal products.

A Review of Intermittent Poisoning to Mitigate Toxic Plant-Induced Disease in Livestock.

Poisonous plants affect livestock and wildlife and in addition to animal disease, they often inhibit the productive use of feeds and natural resources. For some plants, intermittent or cyclic grazing may allow the use of contaminated forages or infested pastures or ranges while avoiding permanent effects of poisoning. The objective of this review is to present several toxic plants for which intermittent poisoning might be an effective management tool.

A Narrative Review of the Vulvar Disease Literature With Images of Women of Color.

Objective: To assess the existing literature on vulvar disease in women of color (WOC).

Methods: A narrative review was conducted to assess the literature on vulvar disease in WOC and evaluate the presence of images in this population. The search encompassed PubMed and OVID using relevant terms related to vulvar conditions and various groups of WOC.