Publications by authors named "K Meyler"
This study examined the antimicrobial susceptibility of invasive meningococcal disease (IMD)-associated Neisseria meningitidis recovered in the Republic of Ireland between 1996 and 2016. In total, 1359 isolates representing over one-third of all laboratory-confirmed cases of IMD diagnosed each epidemiological year (EY; July 1-June 30) were analysed. All isolates were susceptible to ciprofloxacin, rifampicin and cefotaxime and 74% and 87% were susceptible to sulphonamide and penicillin, respectively.
View Article and Find Full Text PDFEpidemiology of Haemophilus influenzae in the Republic of Ireland, 2010-2018.
Eur J Clin Microbiol Infect Dis
December 2020
Article Synopsis
- The study examined the epidemiology of H. influenzae in Ireland, collecting data from 2010 to 2018 and analyzing both invasive and non-invasive infection isolates.
- Most invasive cases were found in children and the elderly, with a notable prevalence in females of childbearing age, while non-typeable H. influenzae (NTHi) was the most common strain identified.
- The research highlighted the effectiveness of the Hib vaccine, but noted emerging concerning trends including increased NTHi prevalence and antibiotic resistance among strains.
Article Synopsis
- The study analyzed the genetic and phenotypic characteristics of Neisseria meningitidis from invasive meningococcal disease cases in the Republic of Ireland between 1996 and 2015, covering periods before and after the introduction of the meningococcal serogroup C conjugate vaccine.
- The predominant serogroups were B and C, with a notable shift from C to B after the MCC vaccine was implemented, despite a general decline in IMD cases.
- The research revealed significant changes in clonal complexes associated with serogroup B, including increased diversity, and highlighted the importance of ongoing surveillance especially after the recent introduction of a menB vaccine.
A carriage study was undertaken (n = 112) to ascertain the prevalence of Neisseria spp. following the eighth case of invasive meningococcal disease in young children (5 to 46 months) and members of a large extended indigenous ethnic minority Traveller family (n = 123), typically associated with high-occupancy living conditions. Nested multilocus sequence typing (MLST) was employed for case specimen extracts.
View Article and Find Full Text PDF