Publications by authors named "K Metowogo"

The African grasscutter (AGC) () is the second largest rodent in sub-Saharan Africa. It is bred for its organoleptic and culinary properties but also serves as a research model. The aim of this study was to investigate the relationship between age-related changes in brain weight, brain volume, and spatial and nonspatial memory performance in the AGC.

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Background: Cancer is leading to premature deaths across the globe. Therapeutic approaches are still being developed to enhance the survival of cancer patients. In our previous study, extracts from four Togolese plants, namely, (CP), (PT), (PP), and (SL), actually used in traditional medicine for cancer treatment, showed beneficial health effects against oxidative stress, inflammation, and angiogenesis.

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Ethnopharmacological Relevance: Cancer is a multistep disease and its management is exceedingly expensive. Nowadays medicinal plants are gaining more attention in drug discovery and approximately 70% of anticancer drugs were developed from natural products or plants. A strong candidate from medicinal plant with anticancer potential should have four major properties: antioxidant, anti-inflammatory, anti-angiogenic, and cytotoxic activities.

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Article Synopsis
  • Combretum micranthum (CM) is a plant widely used in West African traditional medicine for treating various health issues, including kidney disorders.
  • The study aims to investigate the protective effects of a standardized CM extract on kidney damage caused by diabetes in rats and to analyze its bioactive compounds through computational methods.
  • Methodology involved inducing diabetes in rats, treating them with CM extract, and conducting various biochemical tests over eight weeks to assess kidney function and damage.*
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Article Synopsis
  • The study focuses on the toxicity profile of the hydroalcoholic extract from the leaves of Combretum micranthum (CM), which is traditionally used for treating various ailments in West Africa.
  • Researchers conducted acute and sub-chronic toxicity tests on rats to assess potential toxic effects, including behavioral changes and organ health.
  • Results showed no signs of toxicity or adverse effects at high doses, indicating that CM extract may not contain harmful compounds, specifically cyanide, based on Fourier transform infrared spectrophotometry.
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