Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.

We studied the correlation between the effect of α-lipoic acid, emoxipin, reamberin, and mexidol on LPO in vitro and the action of these drugs on insulin sensitivity and tolerance to glucose load in vivo. It was found that the preparations producing prooxidant effect in vitro (α-lipoic acid and reamberin) are characterized by pronounced insulin-potentiating activity, but only slightly increase (α-lipoic acid) or even decrease (reamberin) tolerance to glucose load. 3-Hydroxypyridine derivatives (emoxipin and mexidol) producing an antioxidant effect in vitro increase glucose tolerance, but exhibit relatively weak insulin-potentiating activity.

[Effects of 3-hydroxypyridine and succinic acid derivates on the dynamics of vertebral/neurologic symptoms after the surgical treatment of disk herniations].

A study of 3-hydroxypiridine and succinic acid derivates (emoxipin, reamberin and mexidol) effects on the 14 week dynamics of vertebral/neurologic symptoms was performed in 136 patients after the surgical treatment of disk herniations. Data obtained demonstrated the reduction of severity of neurodystrophic and radicular syndromes without significant changes in dorsalgia, psychological maladaptation (PM) and disability scores (DS) during 3.5 months in patients treated with emoxipin (150 mg i.

[Effects of 3-hydroxypyridine and succinic acid derivatives on the dynamics of dorsalgia and affective disorders after surgical treatment of disc herniation].

A prospective, placebo-controlled randomized study of the effects of 3-hydropxypyridine and succinic acid derivatives (emoxipine, reamberin and mexi the early dynamics of dorsalgia and the corresponding affective disorders has been performed in 136 patients after surgical treatment of lumbal disc hen It is established that a two-week administration of all preparations reduced the manifestations of depression during 3.5 months after spinal surgery. The course of emoxipine (150 mg, i.

Differential patterns in the temporal experession ofBombyx mori chorion genes.

cDNA clones for two distinct families ofBombyx mori chorion protiens, Class A (m2774) and Class Hc (m5000), were used to study the developmental regulation of specific chorion mRNAs. Individual follicles from maturing ovarioles were assayed by Northern blotting techniques and amino acid pulse-labeling to determine concomitant RNA accumulation and protein synthesis patterns with a temporal resolution of 2.2-2.