A recent survey of the entomofauna of the Davis Mountains in the state of Texas has revealed four new species in the genus Fallén (Miridae, Mirinae, Mirini): and found on Liebmann, and and found attracted to lights. Descriptions, habitus, and genitalic images for the new species are included herein. Further, habitus and genitalic photographs of known species from the county are included to aid in identification.
View Article and Find Full Text PDFFull-genome sequences of seven mycobacteriophages isolated from environmental soil samples are presented. These bacteriophages, with their respective clusters or subclusters are Duplo (A2), Dynamo (P1), Gilberta (A11), MaCh (A11), Nikao (K1), Phloss (N), and Skinny (M1). All had siphovirus-like morphologies, with genome sizes ranging from 43,107 to 82,071 bp.
View Article and Find Full Text PDFThis study examines the moderating effects of gender, child abuse, and pathological narcissism on self-reported stalking, sexual harassment, intimate partner violence, and sexual aggression in undergraduate men and women. Child abuse was positively associated with engaging in all forms of interpersonal violence for both genders. For women, pathological narcissism moderated this association such that higher levels of pathological narcissism reduced the association between child abuse and engaging in stalking, sexual harassment, sexual aggression.
View Article and Find Full Text PDFWe describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies to reduce clearance while maintaining a favorable profile. This work led to the identification of a potent BET inhibitor, 2-{8-fluoro-3-[4-(H)methyl-1-methyl-1-1,2,3-triazol-5-yl]-5-[()-(oxan-4-yl)(phenyl)methyl]-5-pyrido[3,2-]indol-7-yl}propan-2-ol (), which demonstrated reduced clearance and an improved pharmacokinetic (PK) profile across preclinical species.
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