Publications by authors named "K McInerney"
Background: This study aims to elucidate ancestry-specific changes to the genomic regulatory architecture in induced pluripotent stem cell (iPSC)-derived oligodendroglia, focusing on their implications for Alzheimer's disease (AD). This work addresses the lack of diversity in previous iPSC studies by including ancestries that contribute to African American (European/African) and Hispanic/Latino populations (Amerindian/African/European).
Methods: We generated 12 iPSC lines-four African, four Amerindian, and four European- from both AD patients and non-cognitively impaired individuals, with varying genotypes ( and ).
Background: Mild cognitive impairment (MCI) is a heterogeneous diagnostic entity, without a clear prognosis, often accompanied by psychiatric symptomatology and physical frailty.
Objective: Understanding the heterogeneity within MCI is a critical step in improving the early detection of cognitive decline and developing effective interventions.
Methods: Cross-sectional multivariate latent mixture analyses of data from patients evaluated between 2015 and 2019, who were routinely entered into a multidisciplinary database for research purposes.
Article Synopsis
- ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), with about half of AD patients having at least one ε4 allele.
- Researchers found that the African-specific A allele of rs10423769 significantly reduces the AD risk associated with ε4 homozygotes by roughly 75%.
- The protective variant is located in a specific region of chromosome 19, demonstrating differences at the structural and DNA methylation levels compared to non-protective variants, and emphasizing the need for diverse ancestry representation in AD studies.
Article Synopsis
- Hispanic/Latino populations, particularly Puerto Ricans, are underrepresented in Alzheimer Disease (AD) genetics research, prompting a study to identify new AD risk loci in this group.
- The study involved Whole Genome Sequencing and analyzed data from 648 Puerto Ricans, adjusting for various factors to ensure accurate results and inferring local ancestry.
- Results revealed a suggestive AD risk locus on chromosome 12 and replicated several known AD genetic loci, emphasizing the need for including diverse populations in genetic studies to improve understanding of AD.
Article Synopsis
- * A retrospective chart review of 23 youths revealed that while 83% initiated treatment, only 42.1% maintained stability on OAT, highlighting a need for further research and better support systems for this age group.
- * The findings suggest the importance of integrated OAT programs tailored for youth, with recommendations for future studies to include collaborative efforts and mixed methods to fully understand youth experiences and treatment outcomes.