Modeling Spatial PM Risk Dynamics and Projecting Disease Burden in Pakistan.

Air pollution, especially small particulate matter (PM.), has emerged as a significant public health crisis in Pakistan, yet its long-term health impacts remain understudied. There is a critical lack of high-resolution spatiotemporal analysis that captures the changing exposure levels and associated mortality trends over extended periods.

Repeating Ponseti method for treating relapsed idiopathic congenital talipes equinovarus in children less than two years of age: a prospective study.

Background: Various conservative and non-conservative methods have been debated for their effectiveness in treating relapsed idiopathic congenital talipes equinovarus (CTEV). The aim of this work was the assessment of repeating Ponseti method in management of relapsed idiopathic CTEV in children less than two years of age.

Methods: This prospective study was carried out on 50 clubfeet in 33 children aged 10 months - two years, who had relapsed idiopathic CTEV after documented complete correction of the initial deformity with Ponseti method and initiation of a bracing protocol, between April 2022 and April 2024.

Biomass-Derived Carbon Dots: Sustainable Solutions for Advanced Energy Storage Applications.

The growing energy demand has underscored the importance of sustainable energy storage devices. Biomass-derived carbon dots (B-Cdots) have gained significant attention for their potential to address this challenge. Utilizing greener routes for the large-scale synthesis of B-Cdots is not only eco-friendly and cost-effective but also promotes sustainability.

Thermo-Mechanical Phase-Field Modeling of Fracture in High-Burnup UO Fuels Under Transient Conditions.

This study presents a novel multiphysics phase-field fracture model to analyze high-burnup uranium dioxide (UO) fuel behavior under transient reactor conditions. Fracture is treated as a stochastic phase transition, which inherently accounts for the random microstructural effects that lead to variations in the value of fracture strength. Moreover, the model takes into consideration the effects of temperature and burnup on thermal conductivity.

Structural and Conformational Impact of Deleterious Spike Protein Mutations in SARS-CoV-2 Omicron Lineages.

Background: A large number of mutations in the Spike (S) protein of the SARS-CoV-2 omicron variant have been noted to alter the receptor binding domain (RBD) and increase the binding surface and enhance the opening of the binding pocket. The cumulative effect of S1 and S2 subunit mutations can influence the conformational dynamics of the binding surface, facilitating the release of viral genome into host cells.

Aim: This study investigates the deleterious mutations across all Omicron lineages identified in our analysis and their effect on the conformational stability of RBD opening.