Monitoring and reporting the composition of plasma and serum to improve biobanks and comparability of extracellular vesicle research: Communication from the ISTH SSC Subcommittee on Vascular Biology.

Transparent reporting is key to improve reproducibility of scientific research. In 2023, the International Society for Extracellular Vesicles (ISEV) updated the "Minimal information for studies of extracellular vesicles" (MISEV) reporting guidelines, and published new recommendations for blood EV research entitled "MIBlood-EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research". The MIBlood-EV recommendations are part of MISEV2023, and promote reporting not only the protocols used for blood collection and handling, but also the composition of the prepared samples that are used to measure extracellular vesicles (EVs).

Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle.

Background: Timely diagnosis of heart failure (HF) in patients with a systemic right ventricle (sRV) is difficult but important since clinical deterioration is fast once HF develops. We aimed to compare echocardiography and biomarker profile between sRV patients with and without HF and patients with a systemic left ventricle diagnosed with HF (sLV-HF).

Methods And Results: Eighty-seven sRV patients and 30 sLV-HF patients underwent echocardiographic evaluation and blood sampling.

Albuminuria Prevalence in Fontan Patients: A Systematic Review and Meta-Analysis.

Patients with a Fontan circulation are at risk for chronic kidney disease (CKD), which is defined as persistently reduced glomerular filtration rate (GFR) <60ml/min/1.73 or elevated marker of kidney injury such as urinary albumin-to-creatinine ratio (UACR) >30mg/g. We determined the prevalence of albuminuria in patients with a Fontan circulation.

Therapeutic potential of DNases in immunothrombosis: promising succor or uncertain future?

Sepsis, a life-threatening condition characterized by systemic inflammation and multiorgan dysfunction, is closely associated with the excessive formation of neutrophil extracellular traps (NETs) and the release of cell-free DNA. Both play a central role in sepsis progression, acting as major contributors to immunothrombosis and associated complications. Endogenous DNases play a pivotal role in degrading NETs and cell-free DNA, yet their activity is often dysregulated during thrombotic disease.