The risk of gastric cancer in carriers of CHEK2 mutations.

CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated with cancers at many sites, including breast and prostate cancers, but the relationship between CHEK2 and gastric cancer has not been extensively studied. In Poland, there are four known founder alleles of CHEK2; three alleles are protein truncating (1100delC, IVS2G>A, del5395) and the other is a missense variant (I157T).

[Ectopic pancreas mimicking advanced gastric malignancy--case report].

Ectopic pancreas is the most common type of ectopic tissue in gastrointestinal tract. It is typically asymptomatic, presenting as a small submucosal lesion in prepyloric region of stomach. The diagnosis is usually incidental, during gastroscopy.

[Serum anti-p53 antibodies in gastric cancer patients].

Unlabelled: Mutation of the p53 gene belongs to the most common genetic alteration in human cancer. Prognostic significance of serum anti-p53 antibodies in patients with gastric cancer is still a matter of controversy. The aim of the study was to estimate the presence of anti-p53 antibodies in serum of gastric cancer patients and relationship between anti-p53 antibodies and chosen clinical and pathomorphological data age, sex, localization of cancer, histology, stage of disease, metastases to lymph nodes and the time of survival.

[Endoscopic septotomy treatment of Zenker's diverticulum].

Unlabelled: The Zenker's diverticulum is the pathology of pharyngo-esophageal region with its neck proximal to the cricopharyngeal muscle. The Zenker's diverticulum is the rare finding in upper endoscopy, but choice of treatment may bring some problems. Nowadays, the flexible endoscopy has been in focus of interest for treatment of Zenker's diverticulum.

The association between the interleukin-1 polymorphisms and gastric cancer risk depends on the family history of gastric carcinoma in the study population.

Objectives: The association between interleukin-1 polymorphisms, H. pylori and increased gastric cancer risk remains controversial.

Aims: To compare the prevalence of these polymorphisms in individuals with two mutually exclusive diseases connected with infection, gastric cancer, and duodenal ulcer.