Publications by authors named "K Margaret MacDougall"
Objective: To investigate the effects of vagus nerve stimulation (VNS) on the seizure frequency in patients with drug-resistant epilepsy (DRE) and bilateral temporal lobe epilepsy (bi-TLE). Additionally, we aimed to determine the safety of VNS and its side effects.
Methods: Our retrospective study included 17 patients with bi-TLE who underwent VNS-device implantation at our center from 1997 to 2019.
Article Synopsis
- The study examines how the slow component of exercise above the lactate threshold affects muscle fatigue during cycling, suggesting a complex relationship between the two.
- Eleven participants performed cycling trials while their muscle fatigue, oxygenation, and pedal forces were measured to understand physiological and mechanical interactions.
- The results showed moderate correlations between muscle fatigue and quadriceps twitch force and oxygenation, but weak correlations with EMG measures and mechanical pedal forces, highlighting individual variability in responses.
The measurement of skeletal muscle fatigue in response to cycling exercise is commonly done in isometric conditions, potentially limiting its ecological validity, and creating challenges in monitoring the time course of muscle fatigue across an exercise bout. This study aimed to determine if muscle fatigue could be reliably assessed by measuring quadriceps twitch force evoked while pedaling, using instrumented pedals. Nine participants completed three laboratory visits: a step incremental test to determine power output at lactate threshold, and on separate occasions, two constant-intensity bouts at a power output 10% above lactate threshold.
View Article and Find Full Text PDFPurpose: Drug-resistant epilepsy (DRE) affects one-third of patients with focal epilepsy. A large portion of patients are not candidates for epilepsy surgery, thus alternative options, such as vagus nerve stimulation (VNS), are proposed. Our objective is to study the effect of vagus nerve stimulation on lesional versus non-lesional epilepsies.
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