Publications by authors named "K Manoharan"

Article Synopsis
  • The study focuses on distinguishing near-field (NF) and far-field (FF) electrograms (EGMs) to better identify critical areas for treating ventricular tachycardia (VT) during ablation procedures, using a new algorithm for EGM analysis.
  • A multicenter study involving 30 patients was conducted, analyzing a massive dataset of EGMs to compare peak frequencies (PF) in different heart rhythms, revealing significant differences that could aid in pinpointing problematic heart circuits.
  • Results indicated that a low-voltage area PF threshold of ≥200 Hz is effective for identifying VT isthmus, with findings suggesting that chronic amiodarone treatment can lower these PF values, potentially impacting treatment outcomes.
View Article and Find Full Text PDF

Background: The footfall and admission rates post-COVID-19 scenario have come down in the case of patients with cardiac problems with larger delays leading to complications as per several studies. Studies have primarily focused on the disruptions due to lockdown but not much study has been done to understand how it has affected the lifestyle of the patients and changed the mentality leading to lower patient arrivals.

Objectives: The current study deals with understanding how the patient arrival pattern has changed and what are the factors affecting the same during COVID-19 times.

View Article and Find Full Text PDF

Acyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals. This review article discusses applications of acyl-1,4-dihydropyridines in organic synthesis since their introduction in 2019.

View Article and Find Full Text PDF

Purpose: Although the Americas and Europe have historically dominated the global research landscape, emerging economies - Brazil, Russia, India, China, and South Africa (BRICS) have significantly increased their contributions in recent years. This article studies clinical trial trends in the BRICS nations between 2018 and 2022 and compares it with trends in the G7 nations (comprising Canada, France, Germany, Italy, Japan, the UK, the USA, and the European Union). This will help stakeholders in planning drug development strategies.

View Article and Find Full Text PDF