Antiviral Properties of HIV-1 Capsid Inhibitor GSK878.

GSK878 is a newly described HIV-1 inhibitor that binds to the mature capsid (CA) hexamer in a pocket originally identified as the binding site of the well-studied CA inhibitor PF-74. Here, we show that GSK878 is highly potent, inhibiting an HIV-1 reporter virus in MT-2 cells with a mean 50% effective concentration (EC) of 39 pM and inhibiting a panel of 48 chimeric viruses containing diverse CA sequences with a mean EC of 94 pM. CA mutations associated with reduced susceptibility to other inhibitors that bind to PF-74 binding site (L56I, M66I, Q67H, N74D, T107N, and Q67H/N74D) also reduced susceptibility to GSK878, with M66I, Q67H/N74D, and L56I having the greatest impact on antiviral activity.

Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: A prospective cohort study within UK Biobank.

Background: Few observational studies have assessed the role of physical activity in oesophago-gastric cancer risk.

Objective: This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer.

Methods: A cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010.

Effects of Age-Related Macular Degeneration on Driving Performance.

Purpose: To explore differences in driving performance of older adults with age-related macular degeneration (AMD) and age-matched controls, and to identify the visual determinants of driving performance in this population.

Methods: Participants included 33 older drivers with AMD (mean age [M] = 76.6 ± 6.

Glaucoma and Driving: On-Road Driving Characteristics.

Purpose: To comprehensively investigate the types of driving errors and locations that are most problematic for older drivers with glaucoma compared to those without glaucoma using a standardized on-road assessment.

Methods: Participants included 75 drivers with glaucoma (mean = 73.2±6.

Deficits of hand coordination and laterality of carotid endarterectomy.

Object: Neurocognitive performance is used to assess multiple cognitive domains, including motor coordination, before and after carotid endarterectomy (CEA). Although gross motor strength is impaired with ischemia of large cortical areas or of the internal capsule, the authors hypothesize that patients undergoing CEA demonstrate significant motor deficits of hand coordination contralateral to the operative side, which is more clearly manifest in the nondominant hand than in the dominant hand with ischemia of smaller cortical areas.

Methods: The neurocognitive performance of 374 patients was evaluated with a battery of neuropsychometric tests.