Contributions of Prof. P. Venkataramaiah to the research on radiation physics and education in India.

Prof. P. Venkataramaiah (P.

Systemic inflammatory syndrome in COVID-19-SISCoV study: systematic review and meta-analysis.

Background: There has been a recent upsurge in the cases of Multisystem inflammatory syndrome in children (MIS-C) associated with Coronavirus disease (COVID-19). We performed a systematic review and meta-analysis on the demographic profile, clinical characteristics, complications, management, and prognosis of this emerging novel entity.

Methods: Using a predefined search strategy incorporating MeSH terms and keywords, all known literature databases were searched up till 10th July 2020.

Rh(III)-Catalyzed Domino [4 + 2] Annulation/Aza-Michael Addition of -(Pivaloyloxy)benzamides with 1,5-Enynes via C-H Activation: Synthesis of Functionalized Aromathecins.

Reported herein are the Rh(III)-catalyzed cascade annulation reactions of -(pivaloyloxy)benzamides with 1,5-enynes to access diversely substituted aromathecin derivatives involving C-H activation. The developed procedure offers an efficient synthetic tool for the assembly of a wide range of -(pivaloyloxy)benzamides and 1,5-enynes with good atom economy and functional group tolerance. The key reactions involved in this annulation are alkyne insertion and aza-Michael addition under oxidant-free mild reaction conditions.

Rh(III)-Catalyzed Cascade Annulations To Access Isoindolo[2,1-b]isoquinolin-5(7H)-ones via C-H Activation: Synthesis of Rosettacin.

An efficient protocol for the synthesis of diversely substituted 7-hydroxyisoindolo[2,1-b]isoquinolin-5(7H)-ones from the reaction of N-(pivaloyloxy)benzamides with 2-alkynyl aldehydes has been developed, which proceeds through sequential alkyne insertion followed by addition of the amide nitrogen on to the aldehyde. This method provided the products with aminal functionality as a handle for further diversification. The synthetic utility of this strategy was successfully illustrated by the concise, two-step synthesis of an alkaloid, rosettacin, and a topoisomerase I inhibitor.