Publications by authors named "K Makedou"
: Lipid dysmetabolism seems to contribute to the development and progression of nonalcoholic fatty liver disease (NAFLD). Our aim was to compare serum lipidomic profile between patients with NAFLD having received monotherapy with vitamin E (400 IU/d) and those having received combination therapy with vitamin E (400 IU/d) and low-dose spironolactone (25 mg/d) for 52 weeks. : This was a study of a randomized controlled trial (NCT01147523).
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- The Oxfordshire Community Stroke Project categorizes ischemic strokes into four types and links hyperglycemia to larger infarct sizes and poorer patient outcomes.
- The study aimed to explore the relationship between glucose fluctuations and stroke types/outcomes using continuous glucose monitoring over 72 hours among recent stroke patients.
- Results indicated that while stroke subtype did not significantly affect mean glucose levels, improving glucose regulation could reduce the odds of poor outcomes, suggesting that strict glucose management might be more effective than focusing on stroke types.
The therapeutic potential of cold physical gas plasma operated at atmospheric pressure in oncology has been thoroughly demonstrated in numerous preclinical studies. The cytotoxic effect on malignant cells has been attributed mainly to biologically active plasma-generated compounds, namely, reactive oxygen and nitrogen species. The intracellular accumulation of reactive oxygen and nitrogen species interferes strongly with the antioxidant defense system of malignant cells, activating multiple signaling cascades and inevitably leading to oxidative stress-induced cell death.
View Article and Find Full Text PDFNesfatin concentrations are positively correlated with beta cell function. However, it is unclear whether diet composition mediates this relationship. We recruited 27 overweight individuals who practiced Orthodox fasting (OF), a subset of the Mediterranean diet (MedDiet), for 7 weeks.
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- - The study investigated how treatments for acute lymphoblastic leukemia (ALL) affect blood lipid levels in children, focusing on genetic factors related to the LpL and APOE genes.
- - Specifically, the APOE gene polymorphism rs429358 showed significant effects on lipid profile changes and was linked to a higher risk classification for some patients.
- - Overall, the findings suggest that lipid abnormalities in pediatric ALL patients might be influenced by their APOE genotype, hinting at a need for more research to explore its potential implications for prognosis.