Publications by authors named "K Majidzadeh-A"
Observing quantum mechanical characteristics in biological processes is a surprising and important discovery. One example, which is gaining more experimental evidence and practical applications, is the effect of weak magnetic fields with extremely low frequencies on cells, especially cancerous ones. In this study, we use a mathematical model of ROS dynamics in cancer cells to show how ROS oscillatory patterns can act as a resonator to amplify the small effects of the magnetic fields on the radical pair dynamics in mitochondrial Complex III.
View Article and Find Full Text PDFLynch syndrome accounts for 3-5% of all colorectal and endometrial cancer cases, and suboptimal management of Lynch syndrome in the Middle East resulted in the underdiagnosis of mutation carriers. Probands from 24 unrelated Iranian families with a history of cancer(s) suggestive of Lynch syndrome underwent microsatellite instability analysis or immunohistochemistry, multigene panel testing, copy number variation detection, or multiplex ligation-dependent probe amplification. Pathogenic variants were identified in five patients (21%), including three in MSH2, one in MSH6, and one in PMS2.
View Article and Find Full Text PDFA family with nine siblings showing signs of Rothmund-Thomson syndrome with two being definitely diagnosed with the syndrome due to homozygous N-terminal mutation of RECQL4.
Clin Case Rep
August 2024
Article Synopsis
- The study focuses on a family with nine children, where two have been confirmed to have RTS2 through genetic testing, while others show potential symptoms of the syndrome.
- It emphasizes the need for healthcare professionals to be vigilant about rare syndromes when diagnosing and treating patients.
- The timely application of genetic counseling and testing could have helped prevent additional births of affected children, highlighting the critical role of genetic testing in managing the risks associated with RTS2, including severe conditions like osteosarcoma.
Multiple primary cancers (MPCs) are defined as the presence of more than one cancer in an individual that is not due to recurrence, metastasis, or local spread. Different factors such as copathogenic genetic mutations, environmental factors, lifestyle, and first cancer treatment increase the possible occurrence of subsequent malignancies. In recent years, the risk of MPCs has increased due to improved treatment; however, quadruple primary malignancies are still rare and require further investigation and treatment of the underlying cause.
View Article and Find Full Text PDFArticle Synopsis
- - Pathogenic mutations in the BRCA1 gene increase the risk of hereditary breast and ovarian cancers, but many mutations are classified as Variants of Unknown Significance (VUS), making their clinical implications unclear.
- - This study focused on identifying regions of the BRCA1 protein that are intolerant to mutations, hypothesizing that higher mutation density correlates with greater intolerance and pathogenicity.
- - Results highlighted the inter-BRCT linker region as particularly intolerant and rich in pathogenic mutations, suggesting its critical role in cancer susceptibility through disruption of BRCA1's interactions.