Legal Issues 101: Implications of Attendance, Absenteeism, and Truancy in the School Setting.

This article is part of Legal Issues 101, a series of topics addressing some common questions and misconceptions about the law and school health. School nurse job responsibilities differ regarding monitoring student attendance and assisting school administrators with required truancy reporting. However, all school nurses support student attendance with a focus on students being safe, healthy, and ready to learn.

School Nursing Associations: Restructuring for Contemporary Practice.

School nursing associations are the professional organizations that help members collaborate with each other, keep up-to-date with trends and advances within the profession, advocate the positions of the profession, and provide a place of connection with stakeholders and government entities. Participation by members in professional associations is waning across the country affecting the work they can do. The Illinois Association of School Nurses took a proactive approach to reorganize and revitalize their organization and membership.

Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC Resistant to Second-Line Antiandrogen Therapy.

Although second-line antiandrogen therapy (SAT) is the standard of care in men with castration-resistant prostate cancer (CRPC), resistance inevitably occurs. One major proposed mechanism of resistance to SAT involves the emergence of androgen receptor (AR) splice variant-7, AR-V7. Recently, we developed MTX-23 using the principle of proteolysis targeting chimera (PROTAC) to target both AR-V7 and AR-full length (AR-FL).

The Cellular Location of Rad23, a Polyubiquitin Chain-Binding Protein, Plays a Key Role in Its Interaction with Substrates of the Proteasome.

Well-studied structural motifs in Rad23 have been shown to bind polyubiquitin chains and the proteasome. These domains are predicted to enable Rad23 to transport polyubiquitylated (polyUb) substrates to the proteasome (Chen and Madura, 2002 [1]). The validation of this model, however, has been hindered by the lack of specific physiological substrates of Rad23.

A role for Saccharomyces cerevisiae Centrin (Cdc31) in mitochondrial function and biogenesis.

Centrins belong to a family of proteins containing calcium-binding EF-hand motifs that perform well-established roles in centrosome and spindle pole body (SPB) duplication. Yeast encodes a single Centrin protein (Cdc31) that binds components in the SPB. However, further studies revealed a role for Centrins in mRNA export, and interactions with contractile filaments and photoreceptors.