Publications by authors named "K Madhan"
Avacopan, a C5a receptor antagonist (C5aR) presents a new therapeutic option to improve outcomes in ANCA-associated vasculitis (AAV). Here we present a case report of a patient initially requiring kidney replacement therapy (KRT), where avacopan was added as an additional adjunctive therapeutic agent late in the treatment course.
View Article and Find Full Text PDFRationale & Objective: Little is known about hospital admissions in nondialysis patients with chronic kidney disease (CKD) before death or starting kidney replacement therapy (KRT).
Study Design: Retrospective observational cohort study.
Setting & Participants: Hospitalizations among 7,201 patients with CKD from 10 public renal clinics in Queensland (QLD), enrolled in the CKD.
Article Synopsis
- A validated measure of vascular access (VA) function is essential for effective hemodialysis (HD), but currently, there is no reliable method to assess this outcome in clinical practice.
- The VALID study aims to evaluate the accuracy and feasibility of measuring VA function using a defined standard over a 6-month period, comparing routine clinical assessments to expert evaluations.
- The study will include approximately 612 participants from diverse dialysis units across multiple countries, focusing on gathering data on the effectiveness, time, and acceptability of the VA function measurement process.
Chronic kidney disease in public renal practices in Queensland, Australia, 2011-2018.
Nephrology (Carlton)
December 2022
Article Synopsis
- This study aimed to profile adults with chronic kidney disease (CKD) in Queensland, Australia, by examining data from 7,060 participants over a median of 3.4 years until they either started kidney replacement therapy (KRT) or passed away without it.
- The cohort was predominantly older (median age 68), with a significant proportion being diabetic and obese; the causes of CKD varied with age, and distinct patterns were observed across different public renal practices.
- The results highlight a broad spectrum of CKD characteristics, including the stability of kidney function in many patients, differing demographics in need of KRT, and significant health disparities notably among Indigenous populations.
Background: Renal biopsy is often required to obtain information for diagnosis, management and prognosis of kidney disease that can be broadly classified into acute kidney injury (AKI) and chronic kidney disease (CKD). The most common conditions identified on renal biopsy are glomerulonephritis and tubulo-interstitial disorders. There is a paucity of information on management strategies and therapeutic outcomes in AKI and CKD patients.
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