Infecting humans with controlled doses of small intestinal helminths, such as human hookworm, is proposed as a therapy for the colonic inflammatory disease ulcerative colitis. Strengthening the colonic mucus barrier is a potential mechanism by which small intestinal helminths could treat ulcerative colitis. In this study, we compare C57BL/6 mice infected with the small intestinal helminth and uninfected controls to investigate changes in colonic mucus.
View Article and Find Full Text PDFApproximately 60 % of older adults with a hospitalized fracture receive post-acute care in a skilled nursing facility (SNF), yet fewer than 10-20 % receive osteoporosis treatment following a fracture. This study sought to understand SNF providers' perspectives on osteoporosis treatment and to receive feedback on a pocketcard to guide osteoporosis treatment in the post-acute care setting. We interviewed 17 SNF providers with 2+ years of post-acute care experience from 13 states.
View Article and Find Full Text PDFInfecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal diseases. However, full-scale clinical trials examining hookworm therapy are limited by the inability to scale-up the production of hookworm larvae to infect sufficient numbers of patients. With the aim of overcoming this challenge, this study infected four healthy individuals with hookworm larvae that had been reanimated from cryopreserved eggs to examine their viability and immunogenicity.
View Article and Find Full Text PDFRealizing positive social and environmental outcomes from assisted ecosystem adaptation requires the management of complex, uncertain, and ambiguous risks. Using assisted coral reef adaptation as a case study, this article presents a conceptual framework that defines social impacts as the physical and cognitive consequences for people of planned intervention and social risks as potential impacts transformed into objects of management through assessment and governance. Reflecting on its multiple uses in the literature, we consider "social risk" in relation to risks to individuals and communities, risks to First Peoples, risks to businesses or project implementation, possibilities for amplified social vulnerability, and risk perceptions.
View Article and Find Full Text PDFBackground: Over 3 million Americans have an opioid use disorder (OUD), and only a fraction receive treatment. Public opinion is crucial in enacting evidence-based policies. Few studies have examined the public's perception of blame for the ongoing opioid overdose epidemic directed at distinct groups.
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