Publications by authors named "K M de Winter de Groot"
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune inflammatory small-vessel disorders with potentially life-threatening organ manifestations. Recent disease definitions and classification criteria allow distinction between granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and non-granulomatous microscopic polyangiitis (MPA). The discovery of ANCA-autoantibodies directed against proteolytic enzymes of neutrophil granules-has enabled earlier diagnosis of AAV and paved the way to stage-adapted treatments.
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- The mammalian pancreas has three key parts: exocrine acini and ducts, along with endocrine islets, all originating from a common progenitor during development.
- Researchers created 18 human fetal pancreas organoid lines from samples between 8-17 weeks of gestation, with four lines showing the ability to produce all three cell types while thriving in culture for over two years.
- Single-cell RNA sequencing revealed LGR5 cells as crucial developmental stem cells, indicating that these organoids are capable of long-term growth and can differentiate into acinar, ductal, and endocrine cells.
Background: The accumulation of calcium load in peripheral lower extremity arteries has been associated with increased severity of peripheral artery disease (PAD) and mortality. While calcium scores are commonly calculated from non-contrast computed tomography (CT) scans, patients with PAD often undergo contrast-enhanced CT scans. This study aims to explore the association between a length-adjusted calcium score (LACS) of the iliofemoral arteries, determined through pre-intervention contrast-enhanced CT, and major adverse events in patients with chronic limb-threatening ischemia (CLTI).
View Article and Find Full Text PDFPost-streptococcal myositis - ultrasound features of an under-recognised disorder: a case report.
BMC Musculoskelet Disord
October 2024
Article Synopsis
- Post-streptococcal myalgia and myositis are rare complications associated with streptococcal infections, and there is limited data available about them, especially in terms of clinical imaging.* -
- A case study of a 31-year-old woman revealed significant muscle pain and changes in her thigh after a streptococcal throat infection and was diagnosed with post-streptococcal myositis through various lab tests and imaging techniques.* -
- This case marks the first report of ultrasound findings in this condition, suggesting that muscle ultrasound can be an effective tool for diagnosing post-streptococcal myalgia and myositis.*
Background: Standardized Nursing Languages (SNLs) have enabled nursing assessments and care to be better documented and visible in electronic health records (EHRs). However, its implementation is challenging and heterogeneous across clinical settings. This study aimed to demonstrate the challenges experienced by members of a European nursing organization, ACENDIO, in implementing SNLs in documentation systems across countries and offer recommendations about its use.
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