Publications by authors named "K M Schmidt-Ott"
Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the population worldwide, accounting for more than 843 million (M) individuals. The prevalence of CKD (844 M patients) is higher than that of diabetes mellitus (422 M patients), cancer (42 M patients), and HIV (37 M patients), but people are often less aware of it. Global expert groups predict reductions in the nephrology workforce in the next decade, with a declining interest in nephrology careers.
View Article and Find Full Text PDFIntroduction: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary condition that causes the formation of cysts primarily in the kidneys. The continuous growth of multiple cysts leads to the destruction of functional parenchyma, which may progress to end-stage kidney disease. Tolvaptan is the only drug specifically approved for slowing down the progression of ADPKD.
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- The study explores the role of 2,3-bisphosphoglycerate mutase (BPGM) in the kidney, highlighting its upregulation during acute kidney injury in both mice and humans.
- Using a specialized mouse model, researchers found that BPGM is mainly located in the distal nephron and its knockout led to rapid kidney injury and structural damage after just four days.
- The absence of BPGM disrupts crucial metabolic processes, elevating oxidative stress and inflammation while linking stress responses between different parts of the nephron, underscoring its importance in kidney function.
Background: Left ventricular hypertrophy (LVH) in patients with end stage renal disease undergoing renal replacement is linked to an increased risk for cardiovascular diseases. Dialysis does not completely prevent or correct this abnormality, and the evidence for kidney transplantation (KT) varies. This analysis aims to explore the relationship between KT and LVH.
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