Publications by authors named "K M SMIRNOV"
Behavioral copying is a key process in group actions, but it is challenging for individuals with autism spectrum disorder (ASD). We investigated behavioral contagion, or instinctual replication of behaviors, in Krushinky-Molodkina (KM) rats ( = 16), a new potential rodent model for ASD, compared to control Wistar rats ( = 15). A randomly chosen healthy Wistar male ("demonstrator rat") was introduced to the homecage of experimental rats ("observers") 10-14 days before the experiments to become a member of the group.
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- The study explores how specific DNA markers related to microRNAs can provide insights into primary osteoporosis, particularly focusing on epigenetic regulation mechanisms.
- Researchers analyzed genetic variants in a cohort of 1,177 individuals from the Volga-Ural region of Russia, looking for connections between these variants and osteoporosis.
- The findings revealed various genetic markers associated with osteoporotic fractures and low bone mineral density, with notable differences based on ethnicity and sex, leading to the development of predictive models for osteoporosis, particularly effective in women.
Molecular dynamics simulations of model charged solid/water interfaces were carried out to provide insight about the relationship between the second-order nonlinear susceptibility χ(2) and the structure of the interfacial water layer. The results of the calculations reveal that the density fluctuations of water extend to about 12 Å from the surface regardless of the system, while the orientational ordering of molecules is long-ranged and is sensitive to the presence of electrolytes. The charge localization on the surface was found to affect only the high-frequency part of the Im[χ(2)] spectrum, and the addition of salt has very little effect on the spectrum of the first water layer.
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- - CRISPR technologies are advanced tools for making precise edits to genomes, and researchers sought more options beyond CRISPR-Cas9 to enhance flexibility and avoid legal issues with intellectual property.
- - MAD7, an engineered type of CRISPR nuclease developed by Inscripta, is presented as a free-to-use alternative for both academic and industrial applications.
- - In a study, CRISPR-MAD7 achieved a high editing rate of up to 90% for specific genes; however, when compared to CRISPR-Cas9, it had lower overall genome-editing efficiency (23% versus 65% for Cas9).
Transcription factors from the WOX family are well-known regulators of cell proliferation and differentiation in plants. Herein, we focused on several genes from the intermediate clade and checked their impact on somatic embryogenesis using the model legume object . As a result, we show that overexpression not only stimulates somatic embryogenesis in the embryogenic line, as it was shown previously, but can also induce somatic embryogenesis in the non-embryogenic line.
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