Publications by authors named "K M Rentsch"
Proteinuria plays a central role in the diagnosis of kidney disease and has a high prognostic value. The test methods used differ considerably regarding impact on test accuracy, sensitivity, and specificity. Therefore, knowledge of the methodology is crucial for the interpretation of the results.
View Article and Find Full Text PDF: Narrow-spectrum beta-lactam antibiotics such as benzylpenicillin and flucloxacillin are increasingly used in outpatient parenteral antimicrobial therapy (OPAT) programs to mitigate the adverse effects associated with broad-spectrum antibiotics. These beta-lactams require continuous administration via portable infusion devices during OPAT. However, the use of benzylpenicillin in OPAT requires special consideration because of its limited stability at elevated temperatures.
View Article and Find Full Text PDFThis study aimed to determine cefazolin target attainment in patients with invasive () infections and to develop a population pharmacokinetic (PK) model. Adult patients with invasive infections treated with cefazolin bolus infusions were included. Unbound and total trough and mid-dose cefazolin concentrations were measured, and strain-specific MICs were determined.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the population pharmacokinetics of flucloxacillin in patients with Staphylococcus aureus bloodstream infections, addressing the challenge of optimal antibiotic dosing due to variations in patient responses.
- Researchers analyzed data from 49 patients using non-linear mixed-effects modeling, revealing that most received a standard 2 g dose every 4 hours, with unique findings on drug concentration dynamics, particularly higher unbound fractions in critically ill patients.
- A web-based app was developed from the model to help optimize flucloxacillin dosing regimens, which is currently undergoing validation in a clinical trial for further testing.