Effects of Building Orientation and Raster Angle on the Mechanical Properties of Selected Materials Used in FFF Techniques.

Advances in the development of additive manufacturing materials (AM) and the low availability of studies on the impact response of AM specimens are the main reasons for this paper. Therefore, the influence of building orientation (vertical and horizontal) and the angle of the raster (15°/-75°, 30°/-60°, 45°/-45°, and 0°/90°) on the tensile and impact strength of AM specimens was investigated. The polylactic acid (PLA)-PolyMax, Mediflex and acrylonitrile-butadiene-styrene (ABS) filaments were chosen to provide a comprehensive characterization of AM materials with versatile mechanical properties.

Deformation Process of 3D Printed Structures Made from Flexible Material with Different Values of Relative Density.

The main aim of this article is the analysis of the deformation process of regular cell structures under quasi-static load conditions. The methodology used in the presented investigations included a manufacturability study, strength tests of the base material as well as experimental and numerical compression tests of developed regular cellular structures. A regular honeycomb and four variants with gradually changing topologies of different relative density values have been successfully designed and produced in the TPU-Polyflex flexible thermoplastic polyurethane material using the Fused Filament Fabrication (FFF) 3D printing technique.

Prediction of consensus binding mode geometries for related chemical series of positive allosteric modulators of adenosine and muscarinic acetylcholine receptors.

Following insights from recent crystal structures of the muscarinic acetylcholine receptor, binding modes of Positive Allosteric Modulators (PAMs) were predicted under the assumption that PAMs should bind to the extracellular surface of the active state. A series of well-characterized PAMs for adenosine (A R, A R, A R) and muscarinic acetylcholine (M R, M R) receptors were modeled using both rigid and flexible receptor CHARMM-based molecular docking. Studies of adenosine receptors investigated the molecular basis of the probe-dependence of PAM activity by modeling in complex with specific agonist radioligands.

Inactivation of Shiga toxin-producing Escherichia coli in lean ground beef by gamma irradiation.

In this study the radiation resistance of 40 Shiga Toxin-Producing Escherichia coli (STEC) isolates which contained various combinations of the shiga toxin 1 (stx1), shiga toxin 2 (stx2), intimin (eae), and hemolysin (ehx) genes were determined. The STEC were suspended in lean ground beef and irradiated at 4 °C. D10 values, the radiation dose needed to reduce 1 log (90%) of a microorganism, ranged from 0.