Publications by authors named "K M Nunley"
Article Synopsis
- Aquatic prey, like the mangrove rivulus, can detect chemical cues to assess predation risk and recognize kin, but it’s unclear how they integrate these cues in response to threats.* -
- A study examined how these fish reacted to alarm cues from either their own lineage or unrelated ones, finding that they reduced activity more in response to unrelated lineage cues, especially in populations that outcross.* -
- The results suggested differences in response to adult vs. embryo cues and hinted that genetic factors, like the major histocompatibility complex, could influence their ability to detect and respond to these chemical signals.*
Background: Recombinant influenza vaccine (RIV) has been in use in US adults since 2013. This study evaluated the safety of quadrivalent recombinant influenza vaccine (RIV4, Flublok® Quadrivalent, Sanofi Pasteur) compared with standard-dose quadrivalent inactivated influenza vaccine (SD-IIV4) in self-identified Chinese adults at Kaiser Permanente Northern California (KPNC).
Methods: This study evaluated adults aged 18-64 years within KPNC during the 2018-2019 influenza season who self-identified as Chinese (NCT03694392).
Aims: We aimed to determine if neuroimaging characteristics of gray and white matter are associated with gait speed in middle-aged individuals with childhood-onset type 1 diabetes (T1D), and whether associations are independent of diabetic peripheral neuropathy (DPN) status.
Methods: In a cohort of 100 middle-aged adults with childhood-onset T1D (aged 49.2 ± 7.
Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and main indication for heart transplantation in children. Therapies specific to pediatric DCM remain limited due to lack of a disease model. Our previous study showed that treatment of neonatal rat ventricular myocytes (NRVMs) with serum from nonfailing or DCM pediatric patients activates the fetal gene program (FGP).
View Article and Find Full Text PDFBackground: The phosphodiesterase 3A (PDE3A) gene encodes a PDE that regulates cardiac myocyte cyclic adenosine monophosphate (cAMP) levels and myocardial contractile function. PDE3 inhibitors (PDE3i) are used for short-term treatment of refractory heart failure (HF), but do not produce uniform long-term benefit.
Objectives: The authors tested the hypothesis that drug target genetic variation could explain clinical response heterogeneity to PDE3i in HF.