Publications by authors named "K M Nave"
Article Synopsis
- Research highlights the significant role of immune processes in the development of Alzheimer's disease, which is the leading cause of dementia.
- Various studies indicate that both innate and adaptive immune responses contribute to the disease's pathology and are influenced by genetics and lifestyle factors.
- New therapeutic approaches targeting neuroinflammation are being explored in clinical settings, offering potential treatment options for Alzheimer's patients.
From early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants' preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months.
View Article and Find Full Text PDFThe seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and other genes expressed in microglia related to immune, lipid, and endocytic functions. We generated a transgenic knockin mouse expressing HaloTag-tagged APOE and optimized experimental protocols for the biochemical purification of APOE, which enabled us to identify fibrillary aggregates of APOE in mice with amyloid-β (Aβ) amyloidosis and in human AD brain autopsies.
View Article and Find Full Text PDFArticle Synopsis
- Hypoxia is increasingly recognized as a key factor that helps brain cells adapt to low oxygen levels and reduced metabolism, leading to what the authors call "functional hypoxia."
- The study investigates the effects of combined mild inspiratory and functional hypoxia during motor-cognitive training in a group of 20 participants, including healthy individuals and those with depression or autism spectrum disorder.
- Initial findings suggest that this training under low oxygen conditions is well-tolerated and may improve well-being, cognitive performance, physical fitness, and affect immune cell responses, warranting further research with a controlled trial to better assess the benefits.