Publications by authors named "K M Mruthunjaya"
Article Synopsis
- Cyclophosphamide (CYL) is a commonly used cancer chemotherapy drug that can lead to severe memory impairment due to its toxic effects from free radical generation.
- A study explored the protective effects of noni fruit juice (NJ), known for its antioxidant properties, against memory issues caused by CYL in Swiss albino mice.
- Results showed that while CYL treatment caused short-term memory impairment, combining NJ with CYL significantly improved memory and biochemical markers associated with oxidative stress and neuroprotection in the mice.
Article Synopsis
- Morinda citrifolia (noni) juice demonstrates potential antioxidant properties and may help prevent cancer by blocking carcinogen-DNA adduct formation.
- The study tested both in vitro (breast cancer cells) and in vivo (mice) to evaluate the anti-tumor effects of noni and its interaction with the chemotherapy drug cyclophosphamide (CYL).
- Results showed that noni improves the cytotoxic effects of CYL, enhances overall tumor inhibition, and alleviates adverse effects on blood parameters and biochemical markers associated with CYL treatment.
Background: Green tea () mouth rinse is found effective in reducing periodontitis. However, studies evaluating the effectiveness of green tea extracts in reducing oral halitosis and tongue coating on Indian population were scanty.
Objective: The objective of this study was to evaluate the effectiveness of green tea-based mouth rinse in comparison with 0.
In this study, we aim to evaluate the anti-diabetic potential of leaves methanolic extract (MeL) using inhibitory assays for α-glucosidase (AG), α-amylase (AM) (carbohydrate digestive enzymes) and aldose reductase (AR) (an enzyme involved in the polyol pathway responsible for glycation). In addition to antidiabetic studies, antioxidant studies were also performed due to the fact that reactive oxygen species (ROS) are produced by various pathways under diabetic conditions. Hyperglycemia induces ROS by activating the glycation reaction and the electron transport chain in mitochondria.
View Article and Find Full Text PDFBioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy and apoptosis, involved in the underlying pathobiology of cancer development and regulation. The pharmacological aiming of the autophagy-apoptosis signaling pathway using phytocompounds hence offers an auspicious method that is complementary to conventional cancer chemotherapy.
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