Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer.

The lack of comprehensive diagnostics and consensus analytical models for evaluating the status of a patient's immune system has hindered a wider adoption of immunoprofiling for treatment monitoring and response prediction in cancer patients. To address this unmet need, we developed an immunoprofiling platform that uses multiparameter flow cytometry to characterize immune cell heterogeneity in the peripheral blood of healthy donors and patients with advanced cancers. Using unsupervised clustering, we identified five immunotypes with unique distributions of different cell types and gene expression profiles.

Osmotic Attraction: A New Mechanism of Nanoparticle Aggregation.

Solvent-induced interactions of nanoparticles in colloidal solutions can substantially affect their physicochemical and transport properties. Predicting these interactions is challenging because the natural causes of the interactions are unclear. Here, we present a comprehensive experimental and theoretical study of the coagulation stability of the surfacted magnetic colloids.

Correction: Shape-controlled anisotropy of superparamagnetic micro-/nanohelices.

Correction for 'Shape-controlled anisotropy of superparamagnetic micro-/nanohelices' by Alexander M. Leshansky , , 2016, , 14127-14138, https://doi.org/10.

Can the Thermophoretic Mobility of Uncharged Colloids Be Predicted?

The thermophoretic motion of nonionic colloids in an inhomogeneous temperature field is due to the solvent-colloid dispersion interactions. The latter form an attractive near-particle "gravity" field that leads to sinking of the colder solvent layers toward a colloid. The spatial extension of this microconvective motion is comparable to the size of the colloids, which prove to be small enough to observe their own regular thermophoretic drift to the cold.