Predicting falls with ultrasound, physical parameters or fall-risk questions among older adults: A prospective cohort study.

Background: Falls are a significant issue among older adults, leading to morbidity and mortality. Screening for fall risk in the ED is crucial but challenging due to time limitations and patient conditions. Sarcopenia, characterized by muscle loss, is associated with increased fall risk, and ultrasound has been proposed as a non-invasive tool to measure muscle mass in this context.

Innovations that helped with accessing and delivering primary care for infants and young children during COVID-19.

Background: For children under age six, regular preventative primary care is needed for administration of vaccinations, surveillance of development, and early diagnosis and intervention for any potential health conditions or developmental delays. The COVID-19 pandemic created many barriers to providing and accessing primary care. While many studies have explored these barriers, it is important to understand how primary care adapted to ensure these crucial early-years appointments were not missed throughout the pandemic.

Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.

Purpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.

Leveraging Observation Research to Improve Instruction for Students With Intellectual Disability: Guidance for Adapting Tools.

Background And Aims: Students with intellectual disability benefit from high-quality instruction in reading and mathematics.

Methods: This Theoretical Paper outlines the need for effective, evidence-based instructional practices for this population and the potential for observation research to inform such advancements. We report our systematic process of adapting two widely used observation tools initially developed for students with learning disabilities, to address content and instructional practices relevant to classrooms serving elementary students with intellectual disability.

Development of Malate Biosensor-Containing Hydrogels and Living Cell-Based Sensors.

Malate is a key intermediate in the citric acid cycle, an enzymatic cascade that is central to cellular energy metabolism and that has been applied to make biofuel cells. To enable real-time sensing of malate levels, we have engineered a genetically encoded, protein-based fluorescent biosensor called Malon specifically responsive to malate by performing structure-based mutagenesis of the Cache-binding domain of the Citron GFP-based biosensor. Malon demonstrates high specificity and fluorescence activation in response to malate, and has been applied to monitor enzymatic reactions in vitro.