Publications by authors named "K M Mahar"
The domestication of Emu (Dromaius novaehollandiae) began in the 1970s, but their productive characteristics have not undergone significant genetic enhancement. This study investigated the inbreeding and genetic diversity of 50 emus from various farms in Japan using Double digest restriction-site associated DNA sequencing (ddRAD-seq) markers. Single nucleotide polymorphism (SNP) calling revealed 1,71,975 high-quality SNPs while runs of homozygosity (ROH) analysis identified 1,843 homozygous segments, with an average of 36.
View Article and Find Full Text PDFBackground: Our study focuses on Yakutian cattle, a Siberian native breed, examining its inbreeding and diversity through genome-wide analysis of runs of homozygosity (ROHs). Yakutian cattle are adapted to Siberia's harsh sub-arctic conditions, enduring temperatures below -70°C. However, the population genetics studies on this breed are scanty, to document the genetic uniqueness in these cattle.
View Article and Find Full Text PDFArticle Synopsis
- - Daprodustat, a new treatment for anemia in chronic kidney disease (CKD) patients, was analyzed to understand how various factors affect its pharmacokinetics in adults, focusing on its absorption, distribution, metabolism, and excretion in dialysis and non-dialysis patients.
- - The study involved data from multiple clinical trials with 707 participants, examining how body weight and the use of certain medications (like clopidogrel) influenced daprodustat's clearance and absorption.
- - Results indicated that daprodustat followed a three-compartment distribution model with specific influences from body weight and dialysis status, while other factors did not significantly impact the drug's effectiveness.
This study investigates the genomic landscape of Sika deer populations, emphasizing the detection and characterization of runs of homozygosity (ROH) and their contribution towards components of fitness. Using 85,001 high-confidence SNPs, the investigation into ROH distribution unveiled nuanced patterns of autozygosity across individuals especially in 2 out of the 8 farms, exhibiting elevated ROH levels and mean genome coverage under ROH segments. The prevalence of shorter ROH segments (0.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the genome sequences of three Indian yak populations and compares them with the Jinchuan yak from China, highlighting the uniqueness and adaptability of Indian yaks in extreme climates.
- - Researchers found 37,437 runs of homozygosity (ROH) across four yak populations, with the Chinese yaks showing higher inbreeding rates, while Indian yaks exhibited more stable and lower inbreeding levels.
- - Five genetic hotspots linked to critical traits for survival, such as hair growth and nutrient response, were identified, suggesting strong natural selection for these traits in adapting to environmental challenges.