Engaging Patients in Discussions About Medication Deprescribing.

Background: Deprescribing, intentional medication discontinuation or dose reduction, can reduce potentially inappropriate medication use and medication-related harms. Engaging patients in deprescribing discussions may increase likelihood of deprescribing and promote shared decision-making.

Objective: To examine the impact of patient-directed educational brochures on patient engagement and deprescribing discussions with primary care providers (PCPs).

Objective Neurophysiological Measures of Cognitive Performance in Elite Ice Hockey Players.

Introduction: Athletic peak performance is increasingly focused on cognitive and mental factors. In the current study, cognitive performance was measured by neurophysiological responses in elite Junior-A hockey players.

Methods: Neurophysiological brain vital signs were extracted from event-related potentials (ERPs) to evaluate auditory sensation (the N100), basic attention (the P300), and cognitive processing (the N400).

Quantification of micro- and nano-plastics in atmospheric fine particles by pyrolysis-gas chromatography-mass spectrometry with chromatographic peak reconstruction.

The effects of micro- and nano-plastics (MNPs) on human health are of global concern because MNPs are ubiquitous, persistent, and potentially toxic, particularly when bound to atmospheric fine particles (PM). Traditional quantitative analysis of MNPs by pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) is often inaccurate because of false positive signals caused by similar polymers and organic compounds. In this study, a reliable analytical strategy combining HNO digestion and chromatographic peak reconstruction was developed to improve the precision of pyrolysis-gas chromatography-mass spectrometry analysis of multiple MNPs bound to PM.

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) for acute poisonings in United States: a retrospective analysis of the Extracorporeal Life Support Organization Registry.

Introduction: Veno-arterial extracorporeal membrane oxygenation is frequently considered and implemented to help manage patients with cardiogenic shock from acute poisoning. However, utilization of veno-venous extracorporeal membrane oxygenation in acutely poisoned patients is largely unknown.

Method: We conducted a retrospective study analyzing the epidemiologic, clinical characteristics and survival of acutely poisoned patients placed on veno-venous extracorporeal membrane oxygenation using the Extracorporeal Life Support Organization registry.

The Effects of Nitric Oxide on Choroidal Gene Expression.

Purpose: Nitric oxide (NO) is recognized as an important biological mediator that controls several physiological functions, and evidence is now emerging that this molecule may play a significant role in the postnatal control of ocular growth and myopia development. We therefore sought to understand the role that nitric oxide plays in visually-guided ocular growth in order to gain insight into the underlying mechanisms of this process.

Methods: Choroids were incubated in organ culture in the presence of the NO donor, PAPA- NONOate (1.