Publications by authors named "K M Lundmark"
The interaction between pancreatic proteases and a serine protease inhibitor purified from potato tubers was investigated by chromatography-coupled light scattering measurements. The molar mass distribution in the chromatogram was compared to theoretical values calculated for the different possible combinations of complexes and free components by three different approaches, namely section analyses of the chromatograms, full mass average determination and mass distribution analysis. This revealed that the inhibitor was able to bind trypsin in a 2:1 complex, whereas the data for chymotrypsin clearly showed a limitation to 1:1 complex regardless of the molar ratio in the injected samples.
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- AA amyloidosis is linked to chronic inflammation and involves the buildup of serum amyloid A protein fragments, with macrophages playing a key role in this process.
- In an experimental mouse model, the study examined how liposomes and an amyloid-enhancing factor affect amyloid formation, revealing that liposomes promote amyloid accumulation but are less effective than the amyloid-enhancing factor.
- The findings indicate that higher levels of intracellular lipids contribute to the formation of AA amyloid fibrils, and the mouse model is valuable for gaining deeper insights into the underlying mechanisms.
Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.
Cold Spring Harb Perspect Med
January 2018
More than 30 proteins form amyloid in humans, most of them outside of the brain. Deposition of amyloid in extracerebral tissues is very common and seems inevitable for an aging person. Most deposits are localized, small, and probably without consequence, but in some instances, they are associated with diseases such as type 2 diabetes.
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