Spectral and Redox Properties of a Recombinant Mouse Cytochrome 561 Protein Suggest Transmembrane Electron Transfer Function.

Cytochrome 561 proteins (CYB561s) are integral membrane proteins with six trans-membrane domains, two heme- redox centers, one on each side of the host membrane. The major characteristics of these proteins are their ascorbate reducibility and trans-membrane electron transferring capability. More than one CYB561 can be found in a wide range of animal and plant phyla and they are localized in membranes different from the membranes participating in bioenergization.

A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.

Objective: To compare the efficacy and safety of two surfactant preparations in the treatment of respiratory distress syndrome (RDS).

Methods: We conducted a randomized, masked comparison trial at 21 centers. Infants with RDS who were undergoing mechanical ventilation were eligible for treatment with two doses of either a synthetic (Exosurf) or natural (Infasurf) surfactant if the ratio of arterial to alveolar partial pressure of oxygen was less than or equal to 0.