Estimates of stroke incidence and case fatality in Zabrze, 2005-2006.

Background And Purpose: Epidemiological rates for stroke obtained in the United States and Western Europe indicate a decrease in incidence and case fatality. Data published for Poland, as for other Central-Eastern European countries, reported unfavourable results, but this was based on data from the 1990s. The authors evaluated current stroke rates in a population study of the southern Poland city of Zabrze.

[Resistance to aspirin in secondary stroke prevention. A pilot study].

Introduction: The purpose of the study was to establish the frequency of aspirin resistance in patients treated in the Department of Neurology in Zabrze with diagnosed transient ischaemic attack (TIA) or ischaemic stroke who used aspirin in the dose of 150 mg daily.

Material And Methods: We examined 20 patients (14 female, 6 male), the mean age 66.8 +/- 11.

[Evaluation of frequency of fatigue syndrome in patients with multiple sclerosis].

Introduction: Fatigue is a common symptom occuring in different neurological diseases. It has an influence on social and proffesional live, and daily living activities of the patients. The aim of the study was to assess frequency of fatigue and its association with depression and anxiety in patients with multiple sclerosis (MS).

[Etiology and clinical signs as short-term risk factors of status epilepticus].

Introduction: The aim of the study was an analysis of causes, clinical symptoms, complications and predictors of an unfavorable course of status epilepticus (SE).

Material And Methods: Retrospective evaluation of medical files of 28 patients (17 M, 11 F, aged 52 +/- 15 yrs) was made. Patients were treated for status epilepticus in a Neurology Clinic in Zabrze between January 1997 and March 2008.

A human antibody against anthrax protective antigen protects rabbits from lethal infection with aerosolized spores.

ALXN4100, a fully human antibody that binds to the protective antigen of anthrax toxin, was generated from a Fab isolated from a phage display library and was analyzed for its pharmacokinetic properties in rabbits and then used to protect rabbits from challenge with a lethal aerosol dose of Bacillus anthracis spores (approximately 322X LD(50)). All rabbits receiving 15 or 40 mg/kg of antibody 24 hours before challenge survived; survival of rabbits receiving 4 mg/kg either subcutaneously or intravenously was 80 or 90%, respectively. Susceptibility to anthrax disease appeared to be correlated with serum antibody concentration.