Effect of hyperlipemia on pulmonary diffusing capacity at rest and during exercise.

Since existing data suggest decreased pulmonary gas exchange at rest when hyperlipemic, the effect of alimentary hyperlipemia on steady-state pulmonary diffusing capacity for carbon monoxide (DLco) at rest and exercise was investigated. Twelve men were measured on two mornings after a 12-hr fast. One trial was performed with subjects in the fasting state, and the other three hours after ingestion of one gm fat per kg body weight.