Publications by authors named "K M Knoll"
Ultrasound localization microscopy (ULM) enables microvascular imaging at spatial resolutions beyond the acoustic diffraction limit, offering significant clinical potentials. However, ULM performance relies heavily on microbubble (MB) signal sparsity, the number of detected MBs, and signal-to-noise ratio (SNR), all of which vary in clinical scenarios involving bolus MB injections. These sources of variations underscore the need to optimize MB dosage, data acquisition timing, and imaging settings in order to standardize and optimize ULM of microvasculature.
View Article and Find Full Text PDFBackground: Wild-type transthyretin cardiac amyloidosis (ATTRwt) is an infiltrative disease leading to restrictive cardiomyopathy. We aimed to characterise exercise capacity in ATTRwt and to identify predictors of cardiopulmonary fitness, focusing on echocardiographic and clinical parameters.
Methods: We studied 110 ATTRwt patients from a prospective single-centre registry (2020-2024) by cardiopulmonary exercise testing (CPET).
Article Synopsis
- Ultrasound microvessel imaging (UMI) shows promise as a noninvasive method to assess microvessel structures in Crohn's disease (CD) by using a quantifiable metric called vessel-length ratio (VLR).
- In a study involving 55 CD patients undergoing surgery, UMI's VLR had a strong correlation (R = 0.80) with pathological inflammation, significantly outperforming color flow imaging (CFI), which had a correlation of R = 0.59.
- UMI not only distinguished between mild and non-mild inflammation more effectively than CFI, but also demonstrated superior performance in a subset of patients with strictures, indicating its potential utility in IBD imaging assessments.
Importance: Aortic stenosis (AS) and coronary artery disease (CAD) frequently coexist. However, it is unknown which genetic and cardiovascular risk factors might be AS-specific and which could be shared between AS and CAD.
Objective: To identify genetic risk loci and cardiovascular risk factors with AS-specific associations.
Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder in Western countries, with approximately 20%-30% of the MASLD patients progressing to severe stages. There is an urgent need for noninvasive, cost-effective, widely accessible, and precise biomarkers to evaluate liver steatosis. This study aims to assess and compare the diagnostic performance of a novel reference frequency method-based ultrasound attenuation coefficient estimation (ACE) in both fundamental (RFM-ACE-FI) and harmonic (RFM-ACE-HI) imaging for detecting and grading liver steatosis.
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