Short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in vivo in Caenorhabditis elegans.

Recent studies in vertebrates and Caenorhabditis elegans have reshaped models of how the axon guidance cue UNC-6/Netrin functions in dorsal-ventral axon guidance, which was traditionally thought to form a ventral-to-dorsal concentration gradient that was actively sensed by growing axons. In the vertebrate spinal cord, floorplate Netrin1 was shown to be largely dispensable for ventral commissural growth. Rather, short range interactions with Netrin1 on the ventricular zone radial glial stem cells was shown to guide ventral commissural axon growth.

Nucleophilic Amination of Aryl Halides with an Azanide Surrogate.

We report the development of an azanide (NH) surrogate which enables the facile conversion of electron-deficient (hetero)aryl halides into primary N-aryl amines under transition-metal-free conditions. The designed amidine reagent is easy to prepare, bench stable, and undergoes facile N-arylation under basic conditions at 40 °C. Intermediate N-aryl amidines are readily cleaved to form N-aryl amines in situ through hydrolysis or base-promoted elimination.

Welcoming new Editorial Advisory Board members.

We welcome five new Editorial Advisory Board members, who help to expand our expertise in areas of cutting-edge disease research and maintain our journal's high publishing standards.

Supporting the evolution of infectious disease research.

In anticipation of our Special Issue, ‘Infectious Disease: Evolution, Mechanism and Global Health’, we celebrate recent advances made in this field and the success of our Infectious Disease Journal Meeting.

Translating multiscale research in rare disease.

This Editorial introduces DMM's new Special Issue on ‘Translating Multiscale Research in Rare Disease’. The Guest Editors reflect on how articles in the issue advance the rare disease research field.