Publications by authors named "K M Hayes"
Importance: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication of COVID-19 infection. Data on midterm outcomes are limited.
Objective: To characterize the frequency and time course of cardiac dysfunction (left ventricular ejection fraction [LVEF] <55%), coronary artery aneurysms (z score ≥2.
Article Synopsis
- Influenza vaccination is crucial to prevent illness and death in nursing home residents, and this study compares the effectiveness of recombinant influenza vaccine versus standard-dose vaccines in this population.
- Conducted across two influenza seasons, the study randomized nursing homes to administer either the recombinant quadrivalent vaccine or the standard vaccine, focusing on residents aged 65 and older.
- The main outcome measured was respiratory-related hospitalization rates, while secondary outcomes included overall mortality and hospitalization for any reason, with a substantial sample size of over 144,000 observations.
Skeletal Muscle Inosine Monophosphate Formation Preserves ∆G During Incremental Step Contractions .
Am J Physiol Regul Integr Comp Physiol
December 2024
The cause and consequences of inosine monophosphate (IMP) formation when ATP declines during muscular contractions are not fully understood. The purpose of this study was to examine the role of IMP formation in the maintenance of the Gibbs free energy for ATP hydrolysis (∆G) during dynamic contractions of increasing workload, and the implications of ATP loss . Eight males (27.
View Article and Find Full Text PDFBackground: NFKB1 encodes p105, which is processed to p50 to mediate canonical nuclear factor-κB (NF-κB) signaling. Although NF-κB is a central driver of inflammation and heterozygous NFKB1 variants are considered the most common monogenic etiologies of common variable immunodeficiency (CVID), few studies have explored how NFKB1 variants shape clinical course or inflammation in CVID.
Objective: We leveraged a regional cohort of patients with CVID with and without heterozygous NFKB1 variants to assess how clinical and inflammatory features of CVID are shaped by the presence of these variants.
Recent studies highlight a persistent increase in subsequent injury risk following a sport-related concussion (SRC) despite clinical recovery. However, markers of persistent alterations in sensorimotor integration have yet to be identified. One possibility is that compensatory adaptation following SRC may only be unmasked during transient periods of high task complexity in specific sensorimotor circuits.
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