Publications by authors named "K M Hartikainen"

Article Synopsis
  • The inflammatory tumor microenvironment (TME) significantly contributes to cancer progression, particularly in prostate cancer.
  • Tumor-associated macrophages (especially M1, pro-inflammatory types) promote cancer stemness while suppressing androgen response in prostate cancer cells.
  • The study suggests that M1 macrophages do this by releasing factors that activate the NFκB signaling pathway, leading to increased expression of cancer stem cell markers like NANOG and KLF4.
View Article and Find Full Text PDF
Article Synopsis
  • Sleep capital is vital for individual and societal well-being, affecting cognitive abilities, mental health, and productivity, which in turn influences economic outcomes.
  • The framework presented explores the link between sleep quality, health, and economic productivity, highlighting significant benefits from investing in sleep health initiatives.
  • Policy recommendations and strategies for workplaces and individuals are proposed to enhance sleep health, emphasizing its importance for a healthier and more productive society.
View Article and Find Full Text PDF

We investigated whether deep reinforcement learning (deep RL) is able to synthesize sophisticated and safe movement skills for a low-cost, miniature humanoid robot that can be composed into complex behavioral strategies. We used deep RL to train a humanoid robot to play a simplified one-versus-one soccer game. The resulting agent exhibits robust and dynamic movement skills, such as rapid fall recovery, walking, turning, and kicking, and it transitions between them in a smooth and efficient manner.

View Article and Find Full Text PDF

Introduction: As burnout has become a global pandemic, there is a call for improved understanding and detection of alterations in brain functions related to it. We have previously reported challenges in executive functions (EFs) in daily life, especially in metacognition, in subjects with occupational burnout, along with alterations in cardiac physiology. In the current study, we focused on the impact of burnout on brain physiology during a task requiring EF.

View Article and Find Full Text PDF

Burnout is becoming a global pandemic jeopardizing brain health, with a huge impact on quality of life, available workforce, and the economy. Knowledge of the impact of burnout on cognition, physiology, and physical activity (PA) in daily life allows for an improved understanding of the health consequences and everyday ramifications of burnout. Twenty-eight volunteers participated in a three-day recording of daily physiology and PA, including heart rate (HR) and daily steps, with a wearable device.

View Article and Find Full Text PDF