Publications by authors named "K M Haapasaari"
Article Synopsis
- - The study explores the potential relationship between chemokines and tumor-infiltrating lymphocytes (TILs) in the prognosis of seminoma, a type of testicular cancer, highlighting the need for more research in this area.
- - Researchers analyzed samples from 25 seminoma patients and 24 controls, finding that chemokine profiles were significantly different in seminoma compared to normal testis, with notable over-expression in TILs.
- - Results suggest that the expression of chemokines and the proliferation marker Ki-67 in TILs could be valuable indicators for predicting relapse and understanding seminoma biology, calling for further studies.
Background/aim: Central nervous system (CNS) involvement in aggressive B-cell lymphoma, either as a primary or secondary event to systemic disease, portends a poor prognosis. This study sought to identify patients at high risk for CNS relapse by analyzing their human leukocyte antigen (HLA) genotypes.
Patients And Methods: We retrospectively examined the HLA genotypes of 164 patients with systemic lymphoma, primary CNS lymphoma, and CNS relapse of systemic lymphoma.
Article Synopsis
- The RNA sequencing study aimed to explore how the transcription factors Twist1 and Zeb1 affect the prognosis of mycosis fungoides (MF), a type of skin cancer.
- Researchers analyzed malignant T-cells from 40 skin biopsies and employed methods like immunohistochemistry to examine protein expression levels and RNA sequencing for gene and pathway analysis.
- The findings indicated that high Twist1 expression is linked to numerous genes involved in immune response and tumor development, suggesting Twist1 plays a significant role in the progression of MF, while Zeb1's role appeared less impactful.
The pathophysiology and the optimal treatment of breast neuroendocrine tumours (NETs) are unknown. We compared the mutational profiles of breast NETs (n = 53) with those of 724 publicly available invasive ductal carcinoma (IDC) and 98 pancreatic NET (PNET) cases. The only significantly different pathogenetic or unknown variant rate between breast NETs and IDCs was detected in the TP53 (11.
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