Functional analysis of SRY variants in individuals with 46,XY differences of sex development.

In mammals, male sexual development is initiated by the expression of the Sex-determining-Region-Y (SRY) gene. SRY contains a highly conserved high mobility group (HMG) box essential for DNA binding and activity. Variants in SRY cause Differences of Sex Development (DSD), accounting for 10-15% of 46, XY gonadal dysgenesis cases.

Immediate Effects of Distinct Intensities of Transcutaneous Spinal Direct Current Stimulation on Chronic Pain: A Randomized Controlled Trial.

This study aimed to assess the immediate effects of transcutaneous spinal direct current stimulation (tsDCS) on pain outcomes, measured using the visual analog scale (VAS) and pressure pain thresholds in a cohort of 55 participants experiencing chronic pain using a controlled, randomized trial with 55 participants allocated into 2 groups: 2 mA and 0.5 mA of tsDCS for 20 min. Anodal stimulation was applied on the 12th thoracic vertebra, with the cathode positioned on the 7th cervical vertebra.

Potential of quartzite and Hevea brasiliensis wood in the production of cement-wood panels.

The incorporation of residues in cement matrices is a viable alternative for obtaining new products for civil construction and a sustainable solution for the disposal of materials discarded by industries. In this context, the objective of the study was to evaluate the potential use of quartzite and particles of Hevea brasiliensis in the production of cement-wood panels. Quartzite residues and Hevea brasiliensis wood particles were obtained and characterized.

Do Progressive Intensities of Transcranial Direct Current Stimulation with and Without 40 Hz Binaural Beats Change Pre-Frontal Cortex Hemodynamics? A Randomized Controlled Trial.

Transcranial direct current stimulation (tDCS) is often reported to have positive effects on brain hemodynamics as well as cognitive performance. Binaural beats (BBs) have also shown the potential to improve cognitive performance. However, we could not find any studies assessing prefrontal hemodynamics using a combination of these techniques or assessing the effects on hemodynamic response at different intensity levels of tDCS (two and three mA).

Eccentric Force and Regional Biceps Femoris Muscle Excitation During Conventional and 80° Hip-Flexed Nordic Curl.

Context: Hamstring injuries are prevalent in high-intensity sports. The lesion often occurs with concomitant knee extension and hip flexion. The Nordic curl has been suggested to prevent such injury, mainly due to its eccentric hamstring activation.