Publications by authors named "K M Damodara Gowda"
Supplementation of diet with Astaxanthin and DHA prevents gestational and lactational undernourishment-induced metabolic derangements in dams: a metabolomic approach.
J Dev Orig Health Dis
November 2024
Article Synopsis
- Nutrition significantly impacts the health of both mothers and their offspring, particularly during critical periods like gestation and lactation, where undernutrition can lead to metabolic disorders such as obesity and cardiovascular diseases.
- A study evaluated the effects of maternal undernutrition on the plasma metabolic profiles of mothers, revealing increased levels of harmful lipids and dysregulated pathways related to cholesterol and hormone metabolism.
- Supplementation with astaxanthin and DHA showed promise in mitigating these negative effects by positively influencing various lipid metabolism pathways, potentially improving health outcomes for both mothers and their offspring.
The goal of this project was to demonstrate that subpopulations of cells in tumors can uniquely fluctuate in size in response to environmental conditions created during drug treatment, thereby acting as a dynamic "rheostat" to create a favorable tumor environment for growth. The cancer modeling used for these studies was subpopulations of melanoma cells existing in cultured and tumor systems that differed in aldehyde dehydrogenase (ALDH) activity. However, similar observations were found in other cancer types in addition to melanoma, making them applicable broadly across cancer.
View Article and Find Full Text PDFDespite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and almost all patients relapse. Poor patient outcomes demonstrate that myeloma cells are "born to survive" which means they can adapt and evolve following treatment. Thus, new therapeutic approaches to combat survival mechanisms and target treatment resistance are required.
View Article and Find Full Text PDFObjective: To examine the acute and chronic effects of reducing prolonged sedentary time (ST) with physical activity (PA) on cognitive and brain health.
Design: Systematic review and meta-analysis.
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