Publications by authors named "K M Coombs"
Thioredoxin-1 protein interactions in neuronal survival and neurodegeneration.
Biochim Biophys Acta Mol Basis Dis
January 2025
Neuronal cell death remains the principal pathophysiologic hallmark of neurodegenerative diseases and the main challenge for treatment strategies. Thioredoxin1 (Trx1) is a major cytoplasmic thiol oxidoreductase protein involved in redox signaling, hence a crucial player in maintaining neuronal health. Trx1 levels are notably reduced in neurodegenerative diseases including Alzheimer's and Parkinson's diseases, however, the impact of this decrease on neuronal physiology remains largely unexplored.
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- Research highlights a critical gap in understanding long COVID (PASC) in children and emphasizes the need for studies that define its characteristics in this age group.
- The objective is to identify common prolonged symptoms in children aged 6 to 17 post-SARS-CoV-2 infection, examining differences between school-age kids and adolescents, as well as potential symptom clusters for future research.
- A multicenter study involved nearly 5,000 participants, revealing that certain symptoms were significantly more prevalent in those with a history of COVID-19 compared to those without.
Background: Chronic pain is a complex disease that requires interprofessional care for effective management. Despite the need for multidisciplinary care, disease and health care inequities can prevent individuals from attaining adequate treatment. Factors such as mental health, cost, and distance to a health care center can contribute to health care accessibility inequality.
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- A new compound called TLD-1433 (Ruvidar™) has strong properties against bacteria, cancer, and some viruses.
- When it was tested, TLD-1433 was found to effectively kill 50% of the H1N1 flu virus without needing special light, and even more when it was activated by light.
- It also worked against other viruses like human coronavirus and Zika, but it needed higher amounts for non-enveloped viruses like adenovirus, and its effectiveness changed depending on temperature and other conditions.
Article Synopsis
- The study explores the immune responses and protective capabilities of a UV-inactivated recombinant vesicular stomatitis virus (rVSV) vector that includes a fusion protein for influenza and a targeting domain for dendritic cells.
- The research demonstrated that both live and UV-inactivated rVSV-EΔM-tM2e induced strong immune responses against various influenza strains, showing effectiveness in protecting mice from H1N1 challenges.
- The findings suggest that UV-inactivated rVSV-EΔM-tM2e could be a viable candidate for developing an inactivated vaccine against multiple strains of influenza.