The Medical Library as a Component of a Medical School Outreach Experience.

The United States is facing a shortage of physicians for minorities and patients in disadvantaged areas. Many medical schools have pipeline programs to promote the interest of minority students in medicine. The Brody School of Medicine at East Carolina University established the Brody RISE program.

SoxB1 Activity Regulates Sensory Neuron Regeneration, Maintenance, and Function in Planarians.

SoxB1 genes play fundamental roles in neurodevelopmental processes and maintaining stem cell multipotency, but little is known about their function in regeneration. We addressed this question by analyzing the activity of the SoxB1 homolog soxB1-2 in the planarian Schmidtea mediterranea. Expression and functional analysis revealed that soxB1-2 marks ectodermal-lineage progenitors, and its activity is required for differentiation of subsets of ciliated epidermal and neuronal cells.

Mendelian-mutationism: the forgotten evolutionary synthesis.

According to a classical narrative, early geneticists, failing to see how Mendelism provides the missing pieces of Darwin's theory, rejected gradual changes and advocated an implausible yet briefly popular view of evolution-by-mutation; after decades of delay (in which synthesis was prevented by personal conflicts, disciplinary rivalries, and anti-Darwinian animus), Darwinism emerged on a new Mendelian basis. Based on the works of four influential early geneticists - Bateson, de Vries, Morgan and Punnett -, and drawing on recent scholarship, we offer an alternative that turns the classical view on its head. For early geneticists, embracing discrete inheritance and the mutation theory (for the origin of hereditary variation) did not entail rejection of selection, but rejection of Darwin's non-Mendelian views of heredity and variation, his doctrine of naturanon facitsaltum, and his conception of "natural selection" as a creative force that shapes features out of masses of infinitesimal differences.

The cardiovascular and metabolic responses to Wii Fit video game playing in middle-aged and older adults.

Aim: The purpose of this study was (a) to assess the cardiovascular and metabolic responses to Wii Fit video games and (b) to determine if Wii Fit video games meet the American College of Sports Medicine guidelines for improving and maintaining cardiorespiratory fitness.

Methods: Twenty men and women (mean±SD age, height, and weight: = 58.1±8.