Dose optimization of TBI-223 for enhanced therapeutic benefit compared to linezolid in antituberculosis regimen.

TBI-223, a novel oxazolidinone for tuberculosis, is designed to provide improved efficacy and safety compared to linezolid in combination with bedaquiline and pretomanid (BPaL). We aim to optimize the dosing of TBI-223 within the BPaL regimen for enhanced therapeutic outcomes. TBI-223 is investigated in preclinical monotherapy, multidrug therapy, and lesion penetration experiments to describe its efficacy and safety versus linezolid.

An examination of undergraduate research in the field of biomechanics across multiple US-based institutions.

Undergraduate research is commonly performed in many STEM disciplines and has a wide array of benefits for students, laboratories, principal investigators, and institutions. While many fields have assessed best practices and the cost-benefit analysis of incorporating undergraduates in research, this has not yet been addressed in biomechanics. This paper represents the perspectives of seven members of the American Society of Biomechanics (ASB) Teaching Biomechanics Interest Group (TBIG).

Characterizing impact and providing perspective by assessing National Biomechanics Day events.

In this Perspective article we make the case for assessing National Biomechanics Day in order to better understand and maximum its impact. We present the opportunities and benefits that exist to assess National Biomechanics Day, as well as suggest assessment resources and tools that can be utilized. A case study is also included that details the ways that including assessment via a pre- and post-National Biomechanics Day survey provided insight into how our event changed student perceptions related to biomechanics, as well as informed us about how we might improve our event in the future.