Publications by authors named "K M Bakulski"
Article Synopsis
- - Loneliness has a complex genetic basis, affecting gene expression linked to inflammation and immune response, but previous studies hadn’t explored how DNA methylation patterns relate to this.
- - In a study involving 281 adult twins' DNA, researchers found no significant methylation differences at the genome-wide level, but identified 25 suggestive sites associated with genes related to inflammation.
- - The study showed a strong correlation between loneliness and accelerated epigenetic aging, indicating that higher loneliness levels might reflect faster biological aging across various systems in the body.
To distinguish DNA methylation (DNAm) from cell proportion changes in whole placental villous tissue research, we developed a robust cell type-specific DNAm reference to estimate cell composition. We collated new and existing cell type DNAm profiles quantified via Illumina EPIC or 450k microarrays. To estimate cell composition, we deconvoluted whole placental samples ( = 36) with robust partial correlation based on the top 30 hyper- and hypomethylated sites identified per cell type.
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- The study explored how self-rated physical and mental work demands affect cognition in older working adults, examining data from 6,377 participants in the 2004 Health and Retirement Study.
- Results indicated that higher physical demands correlated with poorer cognitive performance, while higher mental demands were linked to better cognition, but the relationship between the two demands was interconnected.
- The findings suggest that mental work demands may support cognitive health in older adults, especially when physical demands are low, highlighting the importance of considering interactions between different types of work demands in future research.
Background: Whether including additional environmental risk factors improves cardiovascular disease (CVD) prediction is unclear. We attempted to improve CVD mortality prediction performance beyond traditional CVD risk factors by additionally using metals measured in the urine and blood and with statistical machine learning methods.
Methods: Our sample included 7,085 U.
Major depressive disorder accelerates DNA methylation age, a biological aging marker. Subclinical depressive symptoms are common, but their link to DNA methylation aging in older adults remains unexplored. This study analyzed the cross-sectional relationship between depressive symptoms and accelerated DNA methylation aging, considering gender and race/ethnicity in U.
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