Preparation and evaluation of radiolabeled gliclazide parenteral nanoemulsion as a new tracer for pancreatic β-cells mass.

Purpose: The present investigation aims to develop and evaluate a radiopharmaceutical for targeting and assessing β-cells mass based on gliclazide, an antidiabetic drug that specifically binds the sulfonylurea receptor unique to the β-cells of the pancreas.

Methods: Conditions were optimized to radiolabel gliclazide with radioiodine via electrophilic substitution reaction. Then, it was formulated as a nanoemulsion system using olive oil and egg lecithin by hot homogenization followed by ultrasonication.

Synthesis and biological evaluation of [I]iodocarvedilol as a potential radiopharmaceutical for heart imaging.

The optimization of the radiolabeling yield of carvedilol with iodine-131 was described. Dependence of the labeling yield of [I]iodocarvedilol on the concentration of carvedilol, chloramine-T content, pH of the reaction mixture and reaction time was studied in details. Carvedilol was labeled with iodine-131 at pH 6 with a labeling yield of 92.

Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities.

Two new series of ethyl benzoate bearing pyrrolizine and indolizine moieties 8-11 were synthesized and evaluated for their anti-inflammatory and anticancer activities. Among these derivatives, compounds 9a, 10b and 11b displayed in vivo anti-inflammatory and analgesic activity comparable to ibuprofen. The acute ulcerogenicity and histopathological studies revealed better GIT safety profile than ibuprofen.

Outcome of intracytoplasmic injection of fresh and frozen-thawed testicular spermatozoa. A comparative study.

Objective: To compare the outcomes of intracytoplasmic sperm injection (ICSI) with fresh and cryopreserved testicular spermatozoa in patients with obstructive and nonobstructive azoospermia.

Study Design: Retrospective analysis.

Results: A total of 60 ICSI treatment cycles (32 fresh, 28 frozen) using testicular sperm obtained by open biopsy were analyzed retrospectively.