Publications by authors named "K Luijken"
Article Synopsis
- Prediction models help make medical decisions by estimating risks, advising high-risk individuals to undergo interventions while suggesting low-risk individuals avoid them.
- Traditional models may overlook the complexities of interventions since they often assess risk at just one point in time, while in reality, decisions are made repeatedly and may change over time.
- The article discusses how to formulate estimands for making better sequential predictions about interventions, using the example of choosing between vaginal delivery and cesarean section to inform future research and improve decision-making in clinical practice.
: The estimand framework offers a structured approach to define the treatment effect to be estimated in a clinical study. Defining the estimand upfront helps formulating the research question and informs study design, data collection and statistical analysis methods. Since the Trials within Cohorts (TwiCs) design has unique characteristics, the objective of this study is to describe considerations and provide guidance for formulating estimands for TwiCs studies.
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- Telemedicine shows promise in managing heart failure (HF), but studies yield mixed results, making it difficult to form clear guidelines.
- A scoping review of 15 randomized controlled trials (RCTs) with varied HF patient subgroups revealed inconsistent findings on which patients benefit most from telemedicine.
- Differences in subgroup definitions, study demographics, and the need for ongoing real-world evidence highlight the importance of continuous monitoring to optimize telemedicine strategies in HF management.
Drawing on our experiences conducting replications we describe the lessons we learned about replication studies and formulate recommendations for researchers, policy makers, and funders about the role of replication in science and how it should be supported and funded. We first identify a variety of benefits of doing replication studies. Next, we argue that it is often necessary to improve aspects of the original study, even if that means deviating from the original protocol.
View Article and Find Full Text PDFBackground And Aims: Home treatment is considered safe in acute pulmonary embolism (PE) patients selected by a validated triage tool (e.g. simplified PE severity index score or Hestia rule), but there is uncertainty regarding the applicability in underrepresented subgroups.
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